Special Operations Division is responsible for investigating, prosecuting, and providing support on a number of different crimes and Departmental operations. The Division is comprised of numerous sections of men and women who provide the highest caliber of investigative services and support to the Guilford county Community and law enforcement agencies at every level. Special Operations Division consist of the following units; Major Crimes, Gang Intelligence, Vice/Narcotics, Crime Repression Team, Crime Scene Unit, AFIS, Internet Crimes, Computer Forensics, Traffic Enforcement, Highway Interdiction, Evidence, Mobile Command Unit, and K-9 Sections. Special Operations Division provides support personnel to the DEA Drug Task Force and the FBI Violent Gang Task Force.

The mission of Special Operations Division is to provide a coordinated response to significant policing concerns through the application of highly trained and specialized resources. Special Operations Division provides investigative expertise and to work in partnership with the various communities and Department entities to enhance public safety. Special Operations Division is also committed to supporting other local, state, and law enforcement agencies to ensure a cooperative, successful and unified effort to protect and serve people in all communities.

Captain A. W. Caliendo serves as the commander of the Special Operations Division.